Project

Milestones

  1. Q1

    1. Project launch

    Q2

    1. Launch of project website

    Q3

    1. First successful proofs of concept of modelling drug effects at different scales

    Q4

    1. First use cases building on modelling receptor effects with clozapine & amisulpride
    2. Clinical trial protocol for MOPHRENIA study in Marseille
    3. Identification of pathophysiological mechanisms
    4. First backend of the Virtual Brain Twin software ecosystem

  2. Q2

    1. Deep mechanistic annotation of predictive disease patterns

    Q3

    1. First version of Integrative workflows GUI

    Q4

    1. Processing workflows for two data cohorts from Ludwigs-Maximilian Universität München & Aix-Marseille Université
    2. First multiscale model
    3. First preliminary proof of concept of characterized multiscale & integrated brain model modules
    4. First release of the reduced whole brain model
    5. Functional brain signatures
    6. Preliminary integration in EBRAINS platform

  3. Q2

    1. Individualised multiscale virtual brains of patient
    2. Clinical trial protocol for MOPSYPHAR study in Marseille and Munich
    3. Release of the Virtual Brain Twin software ecosystem

    Q4

    1. Prospective clinical study
    2. Integration of the Virtual Twin ecosystem into EBRAINS and GDPR-compliant ecosystem
    3. Parameter manifolds estimation by computational upscaling using AI
    4. Validation study of the personalised virtual brains in legacy cohorts
    5. Personalisation of the Virtual Twin

  4. Q3

    1. Final version of the Virtual Brain Twin software ecosystem toolset with workflows GUI
    2. Final release of the reduced whole brain pre-optimised model and constrained parameter manifolds

    Q4

    1. Data cohorts FAIR incl. data management plan
    2. Open-access book and report on attitudes to Virtual Brain Twins
    3. Final release of multiscale and integrated brain models
    4. Ongoing result registration for both the MOPHRENIA and MOPSYPHAR studies